Benefícios

• Devido à tecnologia Phytosome, RELISSA® apresenta ação GABAérgica 4x mais potente
• RELISSA® aumenta os níveis de BDNF, uma neutrofina cujos níveis baixos estão associados a diversos distúrbios neurológicos
• RELISSA® pode auxiliar indivíduos com TDAH, TEA, ansiedade e tensão pré-menstrual
• Idosos com demência tratados com RELISSA® apresentaram resultados positivos sobre a cognição a partir da 4ª semana
• Referências
• Material do fornecedor, 2024.
• AKHONDZADEH, S.; NOROOZIAN, M.; MOHAMMADI, M. et al. Melissa officinalis extract in the treatment of patients
• with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol
• Neurosurg Psychiatry. 2003; 74(7): 863-866.
• ANHEYER, D.; LAUCHE, R.; SCHUMANN, D. et al. Herbal medicines in children with attention deficit hyperactivity
• disorder (ADHD): a systematic review. Complement Ther Med. 2017; 30: 14-23.
• ARCEUSZ, A.; WESOLOWSKI, M.; ULEWICZ-MAGULSKA, B. Flavonoids and phenolic acids in methanolic extracts,
• infusions and tinctures from commercial samples of lemon balm. Nat Prod Commun. 2015; 10(6): 977-981.
• AWAD, R.; LEVAC, D.; CYBULSKA, P. et al. Effects of traditionally used anxiolytic botanicals on enzymes of the γaminobutyric acid (GABA) system. Can J Physiol Pharmacol. 2007; 85(9): 933-942.
• AWAD, R.; MUHAMMAD, A.; DURST, T. et al. Bioassay-guided fractionation of lemon balm (Melissa officinalis L.)
• using an in vitro measure of GABA transaminase activity. Phytother Res. 2009; 23(8): 1075–1081
• BANO, A.; HEPSOMALI, P.; RABBANI, F. et al. The possible "calming effect" of subchronic supplementation of a
• standardised phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress
• and poor sleep conditions: results from a prospective, randomised, double-blinded, placebo-controlled clinical
• trial. Front Pharmacol. 2023; 14: 1250560.
• www.farmacam.com.br
• BARANI, M.; SANGIOVANNI, E.; ANGARANO, M. et al. Phytosomes as innovative delivery systems for
• phytochemicals: a comprehensive review of literature. Int J Nanomedicine. 2021; 16: 6983-7022.
• CUI, X.; LIN, Q.; LIANG, Y. Plant-derived antioxidants protect the nervous system from aging by inhibiting
• oxidative stress. Front Aging Neurosci. 2020; 12: 209.
• DUTTA, T.; ANAND, U.; MITRA, S. et al. Phytotherapy for attention deficit hyperactivity disorder (ADHD): a
• systematic review and meta-analysis. Front Pharmacol. 2022; 13: 827411.
• ESPOSITO, D.; BELLI, A.; FERRI, R. et al. Sleeping without prescription: management of sleep disorders in children
• with autism with non-pharmacological interventions and over-the-counter treatments. Brain Sci. 2020; 10(7):
• 441.
• GLIWIŃSKA, A.; CZUBILIŃSKA-ŁADA, J.; WIĘCKIEWICZ, G. et al. The role of brain-derived neurotrophic factor
• (BDNF) in diagnosis and treatment of epilepsy, depression, schizophrenia, anorexia nervosa and alzheimer's
• disease as highly drug-resistant diseases: a narrative review. Brain Sci. 2023;13(2):163.
• GOLSORKHI, H.; QORBANI, M.; SABBAGHZADEGAN, S. et al. Herbal medicines in the treatment of children and
• adolescents with attention-deficit/hyperactivity disorder (ADHD): An updated systematic review of clinical
• trials. Avicenna J Phytomed. 2023; 13(4):338-353.
• KARA M, SAHIN S, RABBANI F et al. A. An in vitro analysis of an innovative standardized phospholipid carrierbased Melissa officinalis L. extract as a potential neuromodulator for emotional distress and related conditions.
• Front Mol Biosci. 2024; 11: 1359177.
• KENNEDY, D.O.; WAKE, G.; SAVELEV, S. et al. Modulation of mood and cognitive performance following acute
• administration of single doses of Melissa officinalis (lemon balm) with human CNS nicotinic and muscarinic
• receptor-binding properties. Neuropsychopharmacology. 2003; 28(10): 1871-1881.
• LU, M.; QIU, Q.; LUO, X et al. Phyto-phospholipid complexes (phytosomes): a novel strategy to improve the
• bioavailability of active constituents. Asian J Pharm Sci. 2019; 14(3): 265-274.
• NASERI M, ARABI MIANROODI R, PAKZAD Z, et al. The effect of Melissa officinalis L. extract on learning and
• memory: involvement of hippocampal expression of nitric oxide synthase and brain-derived neurotrophic factor
• in diabetic rats. J Ethnopharmacol. 2021; 276: 114210.
• NOGUCHI-SHINOHARA, M.; ONO, K.; HAMAGUCHI, T. et al. Safety and efficacy of Melissa officinalis extract
• containing rosmarinic acid in the prevention of Alzheimer's disease progression. Sci Rep. 2020; 10(1): 18627.
• OSTADKARAMPOUR, M.; PUTNINS, E.E. Monoamine oxidase inhibitors: a review of their anti-inflammatory
• therapeutic potential and mechanisms of action. Front Pharmacol. 2021;12: 676239.
• REIN, M.J.; RENOUF, M.; CRUZ-HERNANDEZ, C. et al. Bioavailability of bioactive food compounds: a challenging
• journey to bioefficacy. Br J Clin Pharmacol. 2013; 75(3): 588-602.
• www.farmacam.com.br
• SEPAND, M.R.; SOODI, M.; HAJIMEHDIPOOR, H. et al. Comparison of neuroprotective effects of Melissa officinalis
• total extract and its acidic and non-acidic fractions against a β-induced toxicity. Iran J Pharm Res. 2013; 12(2):
• 415-423.
• SHAKERI, A.; SAHEBKAR, A.; JAVADI, B. Melissa officinalis L. A review of its traditional uses, phytochemistry and
• pharmacology. J Ethnopharmacol. 2016; 188: 204-228.
• ZAM, W.; QUISPE, C.; SHARIFI-RAD, J. An updated review on the properties of Melissa officinalis L.: not exclusively
• anti-anxiety. Front Biosci (Schol Ed). 2022; 14(2): 16.

Formulação

Relissa 100mg

Posologia

Crianças de 6 a 11 anos: ingerir 100 mg de RELISSA®, uma a duas vezes ao dia. A partir de 12 anos: ingerir 200 mg de RELISSA®, uma a duas vezes ao dia.