Descrição

Indicações Doença hepática gordurosa metabólica (DHGM); Reduz gordura visceral; Manejo de comorbidades; referencias: Material do Fornecedor. 2023. 2. Ministério da saúde. Acesso em: https://www.gov.br/saude/ptbr/ assuntos/saude-de-a-a-z/e/esteatose-hepatica. 3. Wong SK, Chin K-Y, Suhaimi FH, Ahmad F, Ima-Nirwana S. Vitamin E As a Potential Interventional Treatment for Metabolic Syndrome: Evidence from Animal and Human Studies. Frontiers in Pharmacology. 8(444) (2017). 4. Azlina, M. N., Nafeeza, M. I., & Khalid, B. A. K. (2005). A comparison between tocopherol and tocotrienol effects on gastric parameters in rats exposed to stress. Asia Pacific journal of clinical nutrition, 14(4), 358. 5. Baliarsingh, S., Beg, Z. H., & Ahmad, J. (2005). T . Atherosclerosis, 182(2), 367- 374. 6. Budin, S. B., Othman, F., Louis, S. R., Bakar, M. A., Das, S., & Mohamed, J. (2009). The effects of palm oil tocotrienol-rich fraction supplementation on biochemical parameters, oxidative stress and the vascular wall of streptozotocininduced diabetic rats. Clinics, 64(3), 235-244. 7. Chin, S. F., Ibahim, J., Makpol, S., Hamid, N. A. A., Latiff, A. A., Zakaria, Z., & Ngah, W. Z. W. (2011). Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study. Nutrition & metabolism, 8(1), 42. 8. Chin, S. F., Hamid, N. A. A., Latiff, A. A., Zakaria, Z., Mazlan, M., Yusof, Y. A. M., & Ngah, W. Z. W. (2008). Reduction of DNA damage in older healthy adults by Tri E® Tocotrienol supplementation. Nutrition, 24(1), 1-10. 9. Fang, F., Kang, Z., & Wong, C. (2010). Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferator-activated receptors. Molecular nutrition & food research, 54(3), 345-352. 10. Gwee Sian Khee, S., Yusof, M., Anum, Y., & Makpol, S. (2014). Expression of senescence-associated microRNAs and target genes in cellular aging and modulation by tocotrienol-rich fraction. Oxidative medicine and cellular longevity, 2014. 11. Muto, C., Yachi, R., Aoki, Y., Koike, T., Igarashi, O., & Kiyose, C. (2012). Gamma-tocotrienol reduces the triacylglycerol level in rat primary hepatocytes through regulation of fatty acid metabolism. Journal of clinical biochemistry and nutrition, 12-97. 12. Qureshi, A. A., Sami, S. A., Salser, W. A., & Khan, F. A. (2002). Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis, 161(1), 199-207. 13. Zaiden, N., WN, Y., Ong, S., VH, T., Nesaretnam, K., & Shiba, S. (2010). Gamma delta tocotrienols reduce hepatic triglyceride synthesis and VLDL secretion. Journal of atherosclerosis and thrombosis, 1008090267-1008090267. 14. Zhao, L., Kang, I., Fang, X., Wang, W., Lee, M. A., Hollins, R. R., & Chung, S. (2015). Gamma-tocotrienol attenuates high-fat diet-induced obesity and insulin resistance by inhibiting adipose inflammation and M1 macrophage recruitment. International Journal of Obesity, 39(3), 438-446. 15. Nair A.B. e S.A. Jacob. simple practice guide for dose conversion between animals and human. Journal of basic and clinical pharmacy, v. 7, n. 2, p. 27, 2016. 16. Reagan-Shaw S., M. Nihal, N. Ahmad. Dose translation from animal to human studies revisited. The FASEB journal, v. 22, n. 3, 2008. 17. Peh HY, Tan WS, Liao W, Wong WS. Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol. Pharmacol Ther. 162 (2016), p.152-69. 18. Wong SK, Chin K-Y, Suhaimi FH, Ahmad F, Ima-Nirwana S. Vitamin E As a Potential Interventional Treatment for Metabolic Syndrome: Evidence from Animal and Human Studies. Frontiers in Pharmacology. 8(444) (2017). 19. Sen CK, Khanna S, Rink C, Roy S. Tocotrienols: the emerging face of natural vitamin E. Vitam Horm. 76 (2017) p.203-61. 20. Fernandes NV, Yeganehjoo H, Katuru R, DeBose-Boyd RA, Morris LL, Michon R, et al. Geranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductase. Exp Biol Med (Maywood). 238(11) (2013), 1265-74. 21. Madan KA, Devaki T. Geraniol, a component of plant essential oils-a review of its pharmacological activities. International Journal of Pharmacy and Pharmaceutical Sciences. 7(4) (2015), p.67-70. 22. Siddiqui S, Khan MR, Siddiqui WA. Comparative hypoglycemicand nephroprotective effects of tocotrienol rich fraction (TRF) frompalm oil and rice bran oil against hyperglycemia induced nephropathy in type 1 diabetic rats. Chem Biol Interact. 188 (2010), p.651–658. 23. Chisté RC, Mercadante AZ, Gomes A, Fernandes E, Lima JLFdC, Bragagnolo N. In vitro scavenging capacity of annatto seed extracts against reactive oxygen and nitrogen species. Food chemistry. 127 (2) (2011) p.419-26. 24. Marcuzzi A, Pontillo A, Leo LD, Tommasini A, Decorti G, Not T, et al. Natural Isoprenoids are Able to Reduce Inflammation in a Mouse Model of Mevalonate Kinase Deficiency. Pediatric Research. 64 (2008), 177. 25. Magosso, Enrico, et al. "Tocotrienols for normalisation of hepatic echogenic response in nonalcoholic fatty liver: a randomised placebo-controlled clinical trial." Nutrition journal 12.1 (2013): 1-8. 26. S. Baliarsingh, Z.H. Beg, J. Ahmad, The therapeutic impacts of tocotrienols in type 2 diabetic patients with hyperlipidemia, Atherosclerosis, Vol. 182(2), 2005, p. 367-374.